Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways

Hypothalamic obesity (HO) is a disabling disease caused by central nervous system (CNS) damage due to neurosurgery, trauma, or tumors, especially in hypothalamus. The pathological mechanism of its neural circuits is still unclear, and there is currently no corresponding drug due to the complex etiol...

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書誌詳細

主要な著者:	Junjie Peng, Yichao Ou, Mingfeng Zhou, Xingqin Wang, Xi’an Zhang, Hao Long, Guangsen Wu, Mengjie Che, Kai Li, Le Yang, Zhu Zhang, Ken Kin Lam Yung, Songtao Qi, Zhanpeng Feng
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-01-01
シリーズ:	Frontiers in Pharmacology
主題:	CaMKK2/AMPK signaling GPCRs hypothalamic obesity melanocortin 4 receptor neuropharmacology setmelanotide
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1730786/full
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