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Necroptotic Cell Death Promotes Adaptive Immunity Against Colonizing Pneumococci

Pore-forming toxin (PFT) induced necroptosis exacerbates pulmonary injury during bacterial pneumonia. However, its role during asymptomatic nasopharyngeal colonization and toward the development of protective immunity was unknown. Using a mouse model of Streptococcus pneumoniae (Spn) asymptomatic co...

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Principais autores: Ashleigh Nichole Riegler, Terry Brissac, Norberto Gonzalez-Juarbe, Carlos J. Orihuela
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-04-01
Serier:Frontiers in Immunology
Fag:
Streptococcus pneumoniae
cell death
necrosis
necroptosis
pore-forming toxin (PFT)
pneumolysin (PLY)
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2019.00615/full
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