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Protective role of tissue-resident Tregs in a murine model of beryllium-induced disease

CD4+ T cells drive the immunopathogenesis of chronic beryllium disease (CBD), and their recruitment to the lung heralds the onset of granulomatous inflammation. We have shown that CD4+ Tregs control granuloma formation in an HLA-DP2 Tg model of CBD. In these mice, beryllium oxide (BeO) exposure resu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shaikh M. Atif, Douglas G. Mack, Allison K. Martin, Andrew P. Fontenot
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical investigation 2022-08-01
Cyfres:JCI Insight
Pynciau:
Mynediad Ar-lein:https://doi.org/10.1172/jci.insight.156098
Tagiau: Ychwanegu Tag
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