The anti-dyskinetic effect of dopamine receptor blockade is enhanced in parkinsonian rats following dopamine neuron transplantation

Graft-induced dyskinesia (GID) is a serious complication induced by dopamine (DA) cell transplantation in parkinsonian patients. We have recently shown that DA D2 receptor blockade produces striking blockade of dyskinesia induced by amphetamine in grafted 6-OHDA-lesioned rats, a model of GID.This st...

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Autori principali:	Eunju Shin, Carlo Lisci, Elisabetta Tronci, Camino Fidalgo, Roberto Stancampiano, Anders Björklund, Manolo Carta
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2014-02-01
Serie:	Neurobiology of Disease
Soggetti:	Graft-induced dyskinesia L-DOPA-induced dyskinesia Parkinson's disease Dopamine D1 receptor Dopamine D2 receptor Eticlopride
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0969996113002805
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