Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vulnerable to environmental insults, cellular protein imbalance and targeted pharmaceuticals. Yet, mechanisms that cells deploy to counteract inhibition of this central regulator are little understood. To...

Description complète

Détails bibliographiques

Auteurs principaux:	Peter Tsvetkov, Marc L Mendillo, Jinghui Zhao, Jan E Carette, Parker H Merrill, Domagoj Cikes, Malini Varadarajan, Ferdy R van Diemen, Josef M Penninger, Alfred L Goldberg, Thijn R Brummelkamp, Sandro Santagata, Susan Lindquist
Format:	Artigo
Langue:	Inglês
Publié:	eLife Sciences Publications Ltd 2015-09-01
Collection:	eLife
Sujets:	proteasome bortezomib HSF1 MG132 heat-shock
Accès en ligne:	https://elifesciences.org/articles/08467
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!