Isorhamnetin attenuates renal interstitial fibrosis by targeting TWEAK/Fn14-mediated epithelial–mesenchymal transition

IntroductionIsorhamnetin (ISO), a prominent active compound found in the fruits of Hippophae rhamnoides L., exhibits various pharmacological activities. Recent studies have demonstrated that ISO possesses a significant renoprotective effect. Nevertheless, the specific targets and mechanisms through...

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Hauptverfasser: Yaping Chen, Wenchuan Luo, Hongxiang Guan, Zixin Chen, Zhihui Chen, Lijuan Xiao, Wen Xu, Mei Huang, Ya Lin, Yuqin Zhang, Weihua Peng, Lihong Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-09-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
isorhamnetin
renal interstitial fibrosis
epithelial mesenchymal transition
TWEAK
Fn14
Online Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1649327/full
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