Isorhamnetin attenuates renal interstitial fibrosis by targeting TWEAK/Fn14-mediated epithelial–mesenchymal transition

IntroductionIsorhamnetin (ISO), a prominent active compound found in the fruits of Hippophae rhamnoides L., exhibits various pharmacological activities. Recent studies have demonstrated that ISO possesses a significant renoprotective effect. Nevertheless, the specific targets and mechanisms through...

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Detalhes bibliográficos

Principais autores:	Yaping Chen, Wenchuan Luo, Hongxiang Guan, Zixin Chen, Zhihui Chen, Lijuan Xiao, Wen Xu, Mei Huang, Ya Lin, Yuqin Zhang, Weihua Peng, Lihong Nan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-09-01
coleção:	Frontiers in Immunology
Assuntos:	isorhamnetin renal interstitial fibrosis epithelial mesenchymal transition TWEAK Fn14
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1649327/full
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