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Microsatellite instability and mismatch repair deficiency in bladder urothelial carcinoma: a Tunisian single-center study

Abstract Background Microsatellite instability (MSI) and deficiency in the human mismatch repair (MMR) system are critical drivers of genomic instability in various cancers. Tumors exhibiting MSI and MMR deficiency (dMMR) have prognostic implications and are associated with differential responses to...

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Autori principali: Ahlem Bdioui, Mariem Akkari, Maroua Krifa, Yosra Souiden, Ethmane Sleimane, Wafa Mokni, Nada Ben Lazrek, Sarra Mestiri, Sihem Hmissa, Nabiha Missaoui
Natura: Artigo
Lingua:Inglês
Pubblicazione: SpringerOpen 2025-05-01
Serie:Journal of the Egyptian National Cancer Institute
Soggetti:
Urothelial carcinoma
Bladder
DMMR
MSI
Immunohistochemistry
PCR
Accesso online:https://doi.org/10.1186/s43046-025-00279-x
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