Sex-based multiomics analysis uncovers metabolic and molecular mediators linking MASH and atherosclerosis

Background & Aims: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in patients with metabolic dysfunction-associated steatohepatitis (MASH). No therapy targets both diseases simultaneously, and a roadblock for discovering new treatments is the lack of animal models t...

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Autors principals:	Sandeep Das, Sumit Kumar Anand, M Peyton McKinney, Koral S.E. Richard, Iqbal Mahmud, Sumati Rohilla, Fabio Arias, Alia Ghrayeb, Bo Wei, Lin Tan, Zhipeng Liu, Dhananjay Kumar, Alexandra C. Finney, Nilesh Pandey, Harpreet Kaur, Rajan Pandit, Xiaolu Zhang, Cyrine Ben Dhaou, Sarah P. Thayer, Babak Razani, Bishuang Cai, Fei Chang, Francisco J. Schopfer, Wanqing Liu, Edward A. Fisher, Sridhar Radhakrishnan, Eyal Gottlieb, A Wayne Orr, Nirav Dhanesha, Arif Yurdagul, Jr., Philip L. Lorenzi, Oren Rom
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-03-01
Col·lecció:	JHEP Reports
Matèries:	MASLD MASH Atherosclerotic cardiovascular disease Animal models Metabolomics Transcriptomics
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2589555925003866
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