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Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis

SR proteins are RNA-binding proteins with one or two RNA recognition motif (RRM)-type RNA-binding domains and a C-terminal region rich in arginine-serine dipeptides. They function in cellular processes ranging from transcription to translation. The best-known SR protein, SRSF1, modulates RNA splicin...

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Auteurs principaux: Vasileios Paschalis, Max F. K. Wills, Philippe De Gusmao Araujo, Christian Lucas, Sumera Tubasum, Shijie Cui, Hesna Kara, Carlos Bueno-Alejo, Marina Santana-Vega, Andrea Taladriz-Sender, Zhengyun Zhao, Alexander Axer, Cyril Dominguez, Alasdair W. Clark, Glenn A. Burley, Andrew J. Hudson, Ian C. Eperon
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2025-12-01
Collection:Frontiers in Molecular Biosciences
Sujets:
RNA splicing helicases
split-APEX
SRSF1
ribosomal biogenesis
spliceosomal assembly
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1714378/full
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