Adipose-Tissue-Derived Mesenchymal Stem Cells Mediate PD-L1 Overexpression in the White Adipose Tissue of Obese Individuals, Resulting in T Cell Dysfunction

The PD-L1/PD-1 immune checkpoint axis is the strongest T cell exhaustion inducer. As immune dysfunction occurs during obesity, we analyzed the impact of obesity on PD-L1/PD-1 expression in white adipose tissue (WAT) in mice and in human white adipocytes. We found that PD-L1 was overexpressed in WAT...

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Príomhchruthaitheoirí:	Assia Eljaafari, Julien Pestel, Brigitte Le Magueresse-Battistoni, Stephanie Chanon, Julia Watson, Maud Robert, Emmanuel Disse, Hubert Vidal
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	MDPI AG 2021-10-01
Sraith:	Cells
Ábhair:	PD-1/PD-L1 immune checkpoints T cell dysfunction adipose-tissue-derived mesenchymal stem cells white adipose tissue inflammation obesity
Rochtain ar líne:	https://www.mdpi.com/2073-4409/10/10/2645
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