Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence

Background: Memantine, which is an FDA-proven drug for the treatment of dementia, exerts its function by blocking the function of NMDA (N-methyl-D-aspartate) receptor, a calcium-permeable ion channel that reduces cytotoxic calcium overload. Chondrocyte senescence is a crucial cellular event that con...

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Autores principales:	Qingmei Cheng, Ke He, Junyu Zhu, Xiaoxiao Li, Xuan Wu, Chao Zeng, Guanghua Lei, Ning Wang, Hui Li, Jie Wei
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-09-01
Colección:	Journal of Orthopaedic Translation
Materias:	Chondrocyte senescence Memantine Mitochondria NMDA receptor Osteoarthritis
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2214031X24000949
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