Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard

Adeno-associated viruses (AAVs) are non-enveloped ssDNA icosahedral T = 1 viruses used as vectors for clinical gene delivery. Currently, there are over 200 AAV-related clinical trials and six approved biologics on the market. As such new analytical methods are continually being developed to characte...

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Autors principals:	Mario Mietzsch, Weijing Liu, Ke Ma, Antonette Bennett, Austin R. Nelson, Keely Gliwa, Paul Chipman, Xiaofeng Fu, Shane Bechler, Robert McKenna, Rosa Viner
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-06-01
Col·lecció:	Molecular Therapy: Methods & Clinical Development
Matèries:	adeno-associated virus gene therapy capsid cryo-EM mass spectrometry ion-exchange chromatography
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2329050123000645
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