A Refined, Controlled 16S rRNA Gene Sequencing Approach Reveals Limited Detection of Cerebrospinal Fluid Microbiota in Children with Bacterial Meningitis

ABSTRACT Advances in both laboratory and computational components of high-throughput 16S amplicon sequencing (16S HTS) have markedly increased its sensitivity and specificity. Additionally, these refinements have better delineated the limits of sensitivity, and contributions of contamination to thes...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Christopher E. Pope, Kathryn B. Whitlock, Paul Hodor, David D. Limbrick, Patrick J. McDonald, Jason Hauptman, Lucas R. Hoffman, Tamara D. Simon
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	American Society for Microbiology 2023-06-01
Rangatū:	Microbiology Spectrum
Ngā marau:	bacterial meningitis cerebrospinal fluid high-throughput sequencing
Urunga tuihono:	https://journals.asm.org/doi/10.1128/spectrum.00361-23
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!