Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant <i>Pseudomonas aeruginosa</i>: In Vivo and In Vitro Evidence

This study correlates in vivo findings in a patient with an extensively drug-resistant (XDR) <i>P. aeruginosa</i> infection who developed resistance to ceftazidime-avibactam (CAZ-AVI) with in vitro results of a 7-day hollow-fiber infection model (HFIM) testing the same bacterial strain. The patient...

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Autors principals:	Inmaculada Lopez-Montesinos, María Milagro Montero, Sandra Domene-Ochoa, Carla López-Causapé, Daniel Echeverria, Luisa Sorlí, Nuria Campillo, Sonia Luque, Eduardo Padilla, Nuria Prim, Santiago Grau, Antonio Oliver, Juan P. Horcajada
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-10-01
Col·lecció:	Antibiotics
Matèries:	ceftazidime/avibactam <i>Pseudomonas aeruginosa</i> multidrug-resistant continuous infusion PK/PD hollow fiber
Accés en línia:	https://www.mdpi.com/2079-6382/11/11/1456
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