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LC–MS/MS method for the quantitation of decitabine and venetoclax in rat plasma after SPE: Application to pharmacokinetic study

This study developed a novel, sensitive and selective LC-MS/MS method for the concurrent determination of DCB and VTX in rat plasma using encorafenib as internal standard (IS). To identify DCB, VTX, and IS, the positive multiple reaction monitoring (MRM) mode was used. Chromatographic separation was...

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Principais autores: Abdulaziz I. Alnasser, Mohamed M. Hefnawy, Abdullah M. Al-Hossaini, Yousef A. Bin Jardan, Adel S. El-Azab, Alaa M. Abdel-Aziz, Abdulrahman M. Al-Obaid, Ibrahim A. Al-Suwaidan, Mohamed W. Attwa, Manal A. El-Gendy
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2023-09-01
coleção:Saudi Pharmaceutical Journal
Assuntos:
LC–MS/MS
Acute myeloid leukemia
Decitabine
Venetoclax
Rat plasma
Pharmacokinetics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1319016423001883
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