Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy
Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery. PARP inhibitors, moreover, can be used to induce synthetic lethality in cells where the homologous recombinat...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2020-03-01
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| Schriftenreihe: | Frontiers in Pharmacology |
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| Online-Zugang: | https://www.frontiersin.org/article/10.3389/fphar.2020.00170/full |
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