Selective inhibition of the kinase DYRK1A by targeting its folding process
Kinase inhibitors are important drugs and usually target the ATP binding pocket of kinases. Here, Kii et al.report a completely new type of kinase inhibitor that specifically targets the protein folding intermediate state, but not the mature form, of the protein kinase DYRK1A.
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| Principais autores: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2016-04-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/ncomms11391 |
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