Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

<p>Abstract</p> <p>Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal astroglia atrophy precedes a restricted and specific β-amyloid...

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Principais autores:	Verkhratsky Alexei, Noristani Harun N, Olabarria Markel, Rodríguez José J
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2011-07-01
Series:	Molecular Neurodegeneration
Assuntos:	Astroglia Alzheimer's disease glutamine synthetase GFAP amyloid beta excitotoxicity hippocampus plasticity
Acceso en liña:	http://www.molecularneurodegeneration.com/content/6/1/55
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