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Fenofibrate decreases the bone quality by down regulating Runx2 in high-fat-diet induced Type 2 diabetes mellitus mouse model

Abstract Background This study is to investigate the effect of fenofibrate on the bone quality of Type 2 diabetes mellitus (T2DM) mouse model. Methods T2DM mouse model was induced by high-fat-diet, and the mice were treated with fenofibrate (100 mg/kg) (DIO-FENO) or PBS (DIO-PBS) for 4 weeks. The bo...

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Principais autores: Tianshu Shi, Ke Lu, Siyu Shen, Qiaoli Tang, Kaijia Zhang, Xiaobo Zhu, Yong Shi, Xianglin Liu, Huajian Teng, Chaojun Li, Bin Xue, Qing Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-10-01
coleção:Lipids in Health and Disease
Assuntos:
Fenofibrate
Bone quality
Runx2
Type 2 diabetes mellitus
Acesso em linha:http://link.springer.com/article/10.1186/s12944-017-0592-5
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