Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism.

In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective condensing enzyme lincosamide synthetase (LS) is expected to be an unusual system combining nonribosomal peptide synthetase (NRPS) components w...

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Autors principals:	Jiri Janata, Stanislav Kadlcik, Marketa Koberska, Dana Ulanova, Zdenek Kamenik, Petr Novak, Jan Kopecky, Jitka Novotna, Bojana Radojevic, Kamila Plhackova, Radek Gazak, Lucie Najmanova
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2015-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC4351081?pdf=render
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