VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma

Abstract VAV2 is an activator of RHO GTPases that promotes and maintains regenerative proliferation-like states in normal keratinocytes and oral squamous cell carcinoma (OSCC) cells. Here, we demonstrate that VAV2 also regulates ribosome biogenesis in those cells, a program associated with poor prog...

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Autors principals:	Natalia Fernández-Parejo, L. Francisco Lorenzo-Martín, Juana M. García-Pedrero, Juan P. Rodrigo, Mercedes Dosil, Xosé R. Bustelo
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-02-01
Col·lecció:	Scientific Reports
Matèries:	Guanosine nucleotide exchange factors RHO GTPases RAC1 RHOA PAK1 ROCK
Accés en línia:	https://doi.org/10.1038/s41598-024-54808-0
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