Novel drug-inducible CRISPRa/i systems for rapid and reversible manipulation of gene transcription
Abstract CRISPR activation and interference (CRISPRa/i) are highly effective tools to regulate transcription by fusing dead Cas9 (dCas9) with transcriptional regulatory factors guided by small guide RNA (sgRNA) in mammalian cells and mice. Still, a controllable gene regulation system is desired to i...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Springer
2025-06-01
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| Seri Bilgileri: | Cellular and Molecular Life Sciences |
| Konular: | |
| Online Erişim: | https://doi.org/10.1007/s00018-025-05786-7 |
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