Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester.
The early atherosclerotic lesion is comprised of foam cell macrophages filled with cholesteryl ester (CE), unesterified cholesterol (UC), and cholesterol oxides. Upon incubation of macrophages with oxidized low density lipoprotein (Ox-LDL), they accumulate UC rather than CE, which was shown to accum...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
1994-05-01
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| coleção: | Journal of Lipid Research |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S0022227520391756 |
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