Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

Abstract Cellular senescence drives aging and age-related dysfunction across multiple tissues, including the brain. Through a high-content, senescent cell-based phenotypic screen of a small panel of natural products, we identified tomatidine, an aglycone of tomatine found in tomatoes, as a previousl...

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Autores principales:	Daniela G Costa, Lucy M Gee, Gung Lee, Lilian Sales Gomez, Ana Catarina Franco, Maria Grazia Vizioli, Karla Valdivieso, Lei J Zhang, Nick Pirius, Helene Martini, Rebecca A Porritt, Dominik Saul, Claudia Cavadas, Scott Ebert, Nathan K LeBrasseur, Sundeep Khosla, João F Passos, Christopher M Adams, Paul D Robbins, Diana Jurk
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer Nature 2026-04-01
Colección:	EMBO Molecular Medicine
Materias:	Brain Aging Senescence Senomorphic Cognition
Acceso en línea:	https://doi.org/10.1038/s44321-026-00400-0
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