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hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis

Abstract Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about...

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Hlavní autoři: Abdolhossein Zare, Saeede Salehi, Jakob Bader, Cornelius Schneider, Utz Fischer, Alexander Veh, Panagiota Arampatzi, Matthias Mann, Michael Briese, Michael Sendtner
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2024-08-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-024-51678-y
Tagy: Přidat tag
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