Anakinra for tocilizumab-refractory febrile infection-related epilepsy syndrome with normal IL-1β levels: a case report

BackgroundFebrile infection-related epilepsy syndrome (FIRES) is a severe epileptic encephalopathy with limited treatment options. Neuroinflammation, particularly involving IL-1β and IL-6, is a key driver. Evidence on sequential use of IL-6 receptor blockade (tocilizumab) followed by IL-1 receptor b...

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Autors principals:	Lijun Zhang, Deyuan Li, Jianjun Wang, Xiao Wang, Wanling Zhao, Guoyan Lu
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-06-01
Col·lecció:	Frontiers in Immunology
Matèries:	anakinra child FIRES IL-1β IL-6 status epilepticus
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1866775/full
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