Combined Chaetocin/Trichostatin A Treatment Improves the Epigenetic Modification and Developmental Competence of Porcine Somatic Cell Nuclear Transfer Embryos

Developmental defects in somatic cell nuclear transfer (SCNT) embryos are principally attributable to incomplete epigenetic reprogramming. Small-molecule inhibitors such as histone methyltransferase inhibitors (HMTi) and histone deacetylase inhibitors (HDACi) have been used to improve reprogramming...

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Bibliografske podrobnosti

Principais autores:	Pil-Soo Jeong, Hae-Jun Yang, Soo-Hyun Park, Min Ah Gwon, Ye Eun Joo, Min Ju Kim, Hyo-Gu Kang, Sanghoon Lee, Young-Ho Park, Bong-Seok Song, Sun-Uk Kim, Deog-Bon Koo, Bo-Woong Sim
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2021-10-01
Serija:	Frontiers in Cell and Developmental Biology
Teme:	chaetocin trichostatin A (TSA) somatic cell nuclear transfer (SCNT) porcine embryonic development epigenetic reprogramming zygotic genome activation
Online dostop:	https://www.frontiersin.org/articles/10.3389/fcell.2021.709574/full
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