Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue

Summary: Genetic loss of Agpat2 in humans and mice results in congenital generalized lipodystrophy with near-total loss of adipose tissue and predisposition to develop insulin resistance, diabetes mellitus, hepatic steatosis, and hypertriglyceridemia. The mechanism by which Agpat2 deficiency results...

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Principais autores:	Anil K. Agarwal, Katie Tunison, Goncalo Vale, Jeffrey G. McDonald, Xilong Li, Philipp E. Scherer, Jay D. Horton, Abhimanyu Garg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-10-01
Colecção:	iScience
Assuntos:	physiology cellular physiology cell biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004223018837
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