Antigen delivery by filamentous bacteriophage fd displaying an anti‐DEC‐205 single‐chain variable fragment confers adjuvanticity by triggering a TLR9‐mediated immune response

Abstract Filamentous bacteriophage fd particles delivering antigenic determinants via DEC‐205 (fdsc‐αDEC) represent a powerful delivery system that induces CD8+ T‐cell responses even when administered in the absence of adjuvants or maturation stimuli for dendritic cells. In order to investigate the...

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Hauptverfasser:	Rossella Sartorius, Luciana D'Apice, Maria Trovato, Fausta Cuccaro, Valerio Costa, Maria Giovanna De Leo, Vincenzo Manuel Marzullo, Carmelo Biondo, Sabato D'Auria, Maria Antonietta De Matteis, Alfredo Ciccodicola, Piergiuseppe De Berardinis
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2015-04-01
Schriftenreihe:	EMBO Molecular Medicine
Schlagworte:	antigen delivery DEC‐205 dendritic cells filamentous bacteriophage TLR9
Online-Zugang:	https://doi.org/10.15252/emmm.201404525
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