Restoring the glioblastoma tumor microenvironment by targeting C5a with the antagonist W54011

Abstract Glioblastoma (GBM) poses a serious challenge due to its aggressive nature and poor prognosis. Tumor mesenchymal stem-like cells (tMSLCs) secrete complement component 5a (C5a), altering the tumor microenvironment (TME) and promoting tumor progression. This study investigated W54011, a C5a an...

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Autores principales:	Yoojung Oh, Jihwan Yoo, Dongkyu Lee, Bongki Ko, Jun Pyo Hong, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Yong-Chul Kim, Seok-Gu Kang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-12-01
Colección:	Scientific Reports
Materias:	Complement component 5a Glioblastoma Tumor mesenchymal stem-like cell Tumor microenvironment Tumorsphere W54011
Acceso en línea:	https://doi.org/10.1038/s41598-025-30853-1
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