Immunogenicity of anti-TNF-α biotherapies.II. Clinical relevance of methods used for anti-drug antibody detection

Immunogenicity of biopharmaceuticals is complex and influenced by both structural and pharmacological factors, and by patient-related conditions such as disease being treated, previous and concomitant therapies and individual immune responsiveness. Essential for tailored therapeutic strategies based...

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Главный автор:	Klaus eBendtzen
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2015-04-01
Серии:	Frontiers in Immunology
Предметы:	Immunogenicity Enzyme-linked immunosorbent assay (ELISA) Anti-drug antibodies Anti-TNF biopharmaceuticals homogeneous mobility-shift assay (HMSA) cell-based reporter-gene assay (RGA)
Online-ссылка:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00109/full
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