Rational tuning of temperature sensitivity of the TRPM8 channel

Abstract Detecting temperature is crucial for the survival of living organisms. Although the temperature sensitive Transient Receptor Potential Melastatin 8 (TRPM8) channel has been identified as the prototypical cold sensor, the mechanisms by which it detects temperature remain elusive. In this stu...

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Bibliografiske detaljer

Principais autores:	Lizhen Xu, Xiao Liang, Yunfei Wang, Han Wen, Wenxuan Zhen, Zhangzhi Xue, Fangfei Zhang, Xiao Yi, Xiaoying Chen, Lidan Hu, Bei Li, Bing Zhang, Zhenfeng Deng, Wei Yang, Shilong Yang, Tiannan Guo, Yi Zhu, Fan Yang
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer Nature 2025-11-01
Serier:	EMBO Reports
Fag:	TRPM8 Channel Temperature Sensing Water–Protein Interactions Conformational Rearrangements
Online adgang:	https://doi.org/10.1038/s44319-025-00630-2
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