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High baseline Tie1 level predicts poor survival in metastatic breast cancer

Abstract Background Angiopoietin growth factors (Angs) regulate angiogenesis and lymphangiogenesis by binding to the endothelial Tie2 receptor. Ang2 expression is elevated in tissue hypoxia and inflammation, which also induce cleavage of the extracellular domain of the orphan Tie1 receptor. Here we...

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Autori principali: Leena Tiainen, Emilia A. Korhonen, Veli-Matti Leppänen, Tiina Luukkaala, Mari Hämäläinen, Minna Tanner, Outi Lahdenperä, Pia Vihinen, Arja Jukkola, Peeter Karihtala, Sonja Aho, Eeva Moilanen, Kari Alitalo, Pirkko-Liisa Kellokumpu-Lehtinen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-07-01
Serie:BMC Cancer
Soggetti:
Tie1
Angiopoietin-2
Angiogenesis
Metastatic breast cancer
Prognostic marker
Accesso online:http://link.springer.com/article/10.1186/s12885-019-5959-8
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