Toll-Like receptor 3-mediated interferon-β production is suppressed by oncostatin m and a broader epithelial-mesenchymal transition program

Abstract Background Patients with Triple Negative Breast Cancer (TNBC) currently lack targeted therapies, and consequently face higher mortality rates when compared to patients with other breast cancer subtypes. The tumor microenvironment (TME) cytokine Oncostatin M (OSM) reprograms TNBC cells to a...

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Autori principali:	Noah M. Chernosky, Ilaria Tamagno, Kelsey L. Polak, E. Ricky Chan, Xueer Yuan, Mark W. Jackson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-11-01
Serie:	Breast Cancer Research
Soggetti:	Triple negative breast cancer Tumor microenvironment Oncostatin M Interferon-β Toll-like Receptor 3 Epithelial-mesenchymal transition
Accesso online:	https://doi.org/10.1186/s13058-024-01918-2
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