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Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs

Background: The archetypal DNA methyltransferase inhibitors, 5-azacytidine (AZA) and 5-aza-2'-deoxycytidine (DAC) are potent antineoplastic agents used in the treatment of mainly, blood malignancies. However, the administration of these drugs is confounded by their hydrolytic lability which decrease...

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主要な著者: Martin Hruby, Khushboo Agrawal, Olivia Policianova, Jiri Brus, Jan Skopal, Pavel Svec, Miroslav Otmar, Petr Dzubak, Petr Stepanek, Marian Hajduch
フォーマット: Artigo
言語:Inglês
出版事項: Palacký University Olomouc, Faculty of Medicine and Dentistry 2016-06-01
シリーズ:Biomedical Papers
主題:
オンライン・アクセス:https://biomed.papers.upol.cz/artkey/bio-201602-0007_Biodegradable_system_for_drug_delivery_of_hydrolytically_labile_azanucleoside_drugs.php
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