Muscle Proteome Analysis of Facioscapulohumeral Dystrophy Patients Reveals a Metabolic Rewiring Promoting Oxidative/Reductive Stress Contributing to the Loss of Muscle Function

Facioscapulohumeral muscular dystrophy (FSHD) is caused by the epigenetic de-repression of the double homeobox 4 (DUX4) gene, leading to asymmetric muscle weakness and atrophy that begins in the facial and scapular muscles and progresses to the lower limbs. This incurable condition can severely impa...

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Autores principales:	Manuela Moriggi, Lucia Ruggiero, Enrica Torretta, Dario Zoppi, Beatrice Arosio, Evelyn Ferri, Alessandra Castegna, Chiara Fiorillo, Cecilia Gelfi, Daniele Capitanio
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2024-11-01
Colección:	Antioxidants
Materias:	facioscapulohumeral muscular dystrophy hexosamine biosynthetic pathway metabolic rewiring proteomics redox cofactors
Acceso en línea:	https://www.mdpi.com/2076-3921/13/11/1406
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