Succinate predisposes mice to atrial fibrillation by impairing mitochondrial function via SUCNR1/AMPK axis

Atrial fibrillation (AF), a major public health concern, is associated with high rates of death and disability. Mitochondrial dysfunction has emerged as a key contributor to the pathophysiology of AF. Succinate, an essential Krebs cycle metabolite, is often elevated in the circulation of patients at...

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Hlavní autoři:	Yudi Zhang, Haoyu Gong, Lingyan Jin, Peng Liu, Jiali Fan, Xinghua Qin, Qiangsun Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-04-01
Edice:	Redox Biology
Témata:	Atrial fibrillation Succinate Mitochondrial dysfunction AMPK Diabetes
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2213231725000898
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