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TET2 and TET3 loss disrupts small intestine differentiation and homeostasis

Abstract TET2/3 play a well-known role in epigenetic regulation and mouse development. However, their function in cellular differentiation and tissue homeostasis remains poorly understood. Here we show that ablation of TET2/3 in intestinal epithelial cells results in a murine phenotype characterized...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ihab Ansari, Llorenç Solé-Boldo, Meshi Ridnik, Julian Gutekunst, Oliver Gilliam, Maria Korshko, Timur Liwinski, Birgit Jickeli, Noa Weinberg-Corem, Michal Shoshkes-Carmel, Eli Pikarsky, Eran Elinav, Frank Lyko, Yehudit Bergman
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2023-07-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-023-39512-3
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