Fludarabine disrupts the STAT1/AhR interaction to attenuate type 1 diabetes by inducing tolerogenic dendritic cells along with targeting effector T cells

Abstract Background Loss of immune homeostasis in Type 1 diabetes (T1D) leads to a dysregulated and autoreactive immune response that destroys pancreatic β cells, causing absolute insulin deficiency. Nevertheless, current strategies for restoring immune homeostasis remain limited. Method Inspired by...

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Ngā kaituhi matua:	Shan-Jie Rong, Chun-Liang Yang, Ke Xiao, Qi-Jie Chen, Jia-Wei Zhao, Yue-Chen Liu, Yan-Chao Guo, Fa-Xi Wang, Xin Li, Xi Luo, Yang Li, Dan-Ni Song, Weikuan Gu, Xiang-Yun Zhu, Shi-Wei Liu, Ping Yang, Maryam S. Al-Motawa, Omar Albagha, Fei Sun, Qi-Lin Yu, Ying Yao, Tian-Tian Yue, Cong-Yi Wang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2026-04-01
Rangatū:	Molecular Medicine
Ngā marau:	Fludarabine Drug repurposing Metabolic reprogramming Tolerogenic dendritic cells Type 1 diabetes
Urunga tuihono:	https://doi.org/10.1186/s10020-026-01483-8
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!