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Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma

Abstract Background SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might be involved in resistance to anti-cancer therapy. Methods We evaluated the prognostic significance of SIRT6 in 37...

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Principais autores: Zhongkai Zhang, Sang Hoon Ha, Young Jae Moon, Usama Khamis Hussein, Yiping Song, Kyoung Min Kim, See-Hyoung Park, Ho Sung Park, Byung-Hyun Park, Ae-Ri Ahn, Sang-A Lee, Su Jin Ahn, Jung Ryul Kim, Kyu Yun Jang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-11-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Osteosarcoma
SIRT6
doxorubicin
apoptosis
DNA damage
Acesso em linha:http://link.springer.com/article/10.1186/s13046-020-01759-9
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