Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes

Abstract The liver is a central organ controlling lipid and cholesterol metabolism and plays a key role in regulating lipoprotein profiles and cardiovascular disease risk. Males and females show clear differences in cholesterol handling and susceptibility to atherosclerosis, but the molecular basis...

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Detalhes bibliográficos

Principais autores:	Lin Chen, Zhanfang Kang, Jennifer Härdfeldt, Ziyi Li, Matteo Pedrelli, Qi Li, Ruining Lyu, Philipp Valina Allo, Taras Sych, Xiangru Zheng, Peibin Lin, Jianwen Zeng, Zhiqiang Huang, Oihane Garcia-Irigoyen, Sviatlana Sukhanava, Paolo Parini, Amélie Bonnefond, Erdinc Sezgin, Bo Angelin, Eckardt Treuter, Rongrong Fan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-70846-w
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