Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling

Ubiquitination is a post-translational modification that regulates cellular processes by altering the interactions of proteins to which ubiquitin, a small protein adduct, is conjugated. Ubiquitination yields various products, including mono- and poly-ubiquitinated substrates, as well as unanchored p...

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Hauptverfasser:	Jessica R. Blount, Kozeta Libohova, Gustavo M. Silva, Sokol V. Todi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-06-01
Schriftenreihe:	Cells
Schlagworte:	<i>Drosophila melanogaster</i> innate immunity NF-κB signaling ubiquitination unanchored poly-ubiquitin
Online-Zugang:	https://www.mdpi.com/2073-4409/9/6/1519
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