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Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+

Loss of endoplasmic reticular (ER) Ca2+ activates store-operated Ca2+ entry (SOCE) by causing the ER localized Ca2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here, we demonstrate a novel mechanism by which the inositol 1,4,5 tri...

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Principais autores: Pragnya Chakraborty, Bipan Kumar Deb, Vikas Arige, Thasneem Musthafa, Sundeep Malik, David I Yule, Colin W Taylor, Gaiti Hasan
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2023-07-01
Serier:eLife
Fag:
human neural progenitors cells
human neuronal cells
endoplasmic reticulum
plasma membrane contact sites
Orai
STIM
Online adgang:https://elifesciences.org/articles/80447
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