In silico toxicity assessment and trace level quantification of two genotoxic impurities in silodosin using capillary gas chromatography

Abstract A capillary gas chromatographic method using flame ionization detection was developed and validated for the trace quantification of 2-bromoethanol (2-BE) and 2-bromoethylmethanesulfonate (2-BEM) in silodosin, used in the treatment of benign prostatic hyperplasia. Chromatographic separation...

Description complète

Détails bibliographiques

Auteurs principaux:	Ravi Kiran Panchakarla, Punna Rao Ravi, Manidhar Syam Kumar Buddha, Sumanth Mullangi, Venkata Gowri Chandra Sekhar Kondapalli
Format:	Artigo
Langue:	Inglês
Publié:	SpringerOpen 2023-02-01
Collection:	Journal of Analytical Science and Technology
Sujets:	Gas chromatography Matrix precipitation Genotoxic impurity In silico toxicity Method validation
Accès en ligne:	https://doi.org/10.1186/s40543-023-00378-1
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!