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Identification and Biological Characterization of the Pyrazolo[3,4-<i>d</i>]pyrimidine Derivative SI388 Active as Src Inhibitor

Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our <i>in-house</i> library of pyrazolo[3,4-<i>d</i>]pyrimidines that are active as Src and/or Bcr-Abl TK inhibitors and performed...

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Huvudupphov: Claudia Contadini, Claudia Cirotti, Anna Carbone, Mehrdad Norouzi, Annarita Cianciusi, Emmanuele Crespan, Cecilia Perini, Giovanni Maga, Daniela Barilà, Francesca Musumeci, Silvia Schenone
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2023-07-01
Serie:Pharmaceuticals
Ämnen:
Src kinase
glioblastoma
radiotherapy resistance
pyrazolo[3,4-<i>d</i>]pyrimidines
Länkar:https://www.mdpi.com/1424-8247/16/7/958
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