An agomir of miR-144-3p accelerates plaque formation through impairing reverse cholesterol transport and promoting pro-inflammatory cytokine production.

AIMS: ATP-binding cassette transporter A1 (ABCA1) mediates the efflux of cholesterol and phospholipids to lipid-poor apolipoproteins, which then form nascent HDL, a key step in the mechanism of reverse cholesterol transport (RCT). While a series of microRNAs (miRNAs) have been identified as potent p...

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Autores principales:	Yan-Wei Hu, Ya-Rong Hu, Jia-Yi Zhao, Shu-Fen Li, Xin Ma, Shao-Guo Wu, Jing-Bo Lu, Yu-Rong Qiu, Yan-Hua Sha, Yan-Chao Wang, Ji-Juan Gao, Lei Zheng, Qian Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2014-01-01
Colección:	PLoS ONE
Acceso en línea:	http://europepmc.org/articles/PMC3986368?pdf=render
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