Dynamic coupling of fast channel gating with slow ATP-turnover underpins protein transport through the Sec translocon

Abstract The Sec translocon is a highly conserved membrane assembly for polypeptide transport across, or into, lipid bilayers. In bacteria, secretion through the core channel complex—SecYEG in the inner membrane—is powered by the cytosolic ATPase SecA. Here, we use single-molecule fluorescence to in...

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Bibliografische Detailangaben

Hauptverfasser:	Joel A Crossley, William J Allen, Daniel W Watkins, Tara Sabir, Sheena E Radford, Roman Tuma, Ian Collinson, Tomas Fessl
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2023-12-01
Schriftenreihe:	The EMBO Journal
Schlagworte:	Dynamic Allostery Protein Translocation SecYEG SecA Single‐Molecule FRET
Online-Zugang:	https://doi.org/10.1038/s44318-023-00004-1
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