Stem cell-derived secretome and dental pulp stem cells enhance sciatic nerve regeneration in a rat sciatic neurotmesis model using chitosan nerve conduits

IntroductionPeripheral nerve injuries remain a major clinical challenge, often leading to long-term motor and sensory deficits. Stem cell-based and cell-free approaches, combined with biomaterial scaffolds, have emerged as promising strategies for nerve repair.MethodsThis study evaluated the regener...

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Hauptverfasser:	Bruna Lopes, Ana Catarina Sousa, Alícia de Sousa Moreira, Patrícia Sousa, Justina Prada, Isabel Pires, Bruna Silva, Filipa João, Sandra Amado, Stefania Raimondo, Miriam Metafune, Simona Rando, Ana L. Luís, Stefano Geuna, Rui Alvites, Ana Colette Maurício
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-04-01
Schriftenreihe:	Frontiers in Cell and Developmental Biology
Schlagworte:	conditioned medium dental pulp stem cells nerve conduit peripheral nerve injury regenerative medicine
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1778085/full
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