Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection

Urinary neutrophils are a hallmark of urinary tract infection (UTI), yet the mechanisms governing their activation, function, and efficacy in controlling infection remain incompletely understood. Tamm-Horsfall glycoprotein (THP), the most abundant protein in urine, uses terminal sialic acids to bind...

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Main Authors: Vicki Mercado-Evans, Holly Branthoover, Claude Chew, Camille Serchejian, Alexander B. Saltzman, Marlyd E. Mejia, Jacob J. Zulk, Ingrid Cornax, Victor Nizet, Kathryn A. Patras
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2025-01-01
Serier:JCI Insight
Fag:
Immunology
Infectious disease
Online adgang:https://doi.org/10.1172/jci.insight.180024
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