Mechanisms of SGLT inhibitor action and physiological mediators: systematic review and protocol for the MOSAIC collaborative meta-analysis

Introduction Sodium-glucose cotransporter (SGLT) inhibitors have shown substantial benefit in reducing cardiovascular and kidney events across diverse clinical populations, but the underlying physiological mechanisms remain unclear. However, existing mechanistic studies on renal and cardiovascular h...

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Hlavní autoři:	Daan J Touw, Roland Schmieder, Morten Schou, Shoichi Maruyama, Max Nieuwdorp, Caroline Michaela Kistorp, Piero Ruggenenti, Esben Laugesen, Daniël H van Raalte, Frederik Persson, Jesper Jensen, Annalisa Perna, Georgios Kalambokis, Juan Pablo Díaz Martinez, Frederik Husum Mårup, Massar Omar, Ani Orchanian-Cheff, Eugenio Cersosimo, Sunita Singh, Sawako Kato, Luxcia Kugathasan, Massimo Nardone, Leif Erik Lovblom, Steffen Nielsen, Viktor Rotbain, Agota Kazup, Soren Gullaksen, Liv Vernstrom, Michael J B van Baar, Erik van Bommel, Dennis Kannenkeril, Rosalie Scholtes, Anne Hesp, Charlotte Mosterd, Hiddo Lambers Heerspink, Merle Krebbe, Jaap Joles, Kine Kvitne, Frank Mose, Barbara Geist, Ilias Tsiakas, David Cherney, Vikas Srinivasan Sridhar, Marcel HA Muskiet
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMJ Publishing Group 2026-02-01
Edice:	BMJ Open
On-line přístup:	https://bmjopen.bmj.com/content/16/2/e108946.full
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